uBiome project to sequence the bacteria that live on us

Researchers will be testing swabs taken from thousands of paying volunteers.

(Credit:
uBiome Project)

Oxford University Ph.D. student Jessica Richman, who today finished raising some $350,000 from more than 2,500 people wanting to take part in the uBiome project, isn't shying away from reality: "Yes, we are going to be sampling people's poo," she told the Guardian this week.

And for the squeamish, she offered an asterisk: "You'll only have to wipe it on the toilet paper."

The uBiome project is a "citizen science" effort to sequence the genomes of the trillions of bacteria that colonize our bodies and likely play pivotal roles, both good and bad, in our health.

By sequencing the bacteria of volunteers (provided via Q-tips swabs of mouths, noses, ears, genitals, and guts) at a lab at the University of California in San Francisco, and then having volunteers log into a Web site to complete health surveys, Richman and her team hope to eventually understand what causes a range of health issues, from breast cancer and Crohn's to dementia and chronic obstructive pulmonary disease.

The uBiome project has far surpassed its original $100,000 goal (deadline was this morning). Apparently plenty of people are not afraid to sample their own feces.

And it turns out that sequencing the many strains of bacteria that live in and on our bodies -- known as the "microbiome" -- may be every bit as complicated as sequencing the human genome; after all, microbes outnumber human cells 10 to 1, according to the researchers.

The results may provide a good deal of information about the roots of various health issues given that "about 30 percent of the small molecules found in the blood come from the microbiome," Richman said. "So it certainly looks like some of the illnesses we see are linked to it."

Various studies are implicating specific strains of bacteria in a range of health outcomes, both good and bad. The science gets extremely complex, though, because the bacteria do not live in a vacuum and are interacting with other bacteria all the time.

Richman, who calls this "exploratory science," does not shy away from the challenge and hopes to discover correlations between bacteria strains and health outcomes to better understand both health and disease.

Meanwhile, volunteers who have paid into the project have the option to not only access details gleaned from their own, er, swabs, but to share that data if they choose. "Your data is yours -- you can download it, share it, do whatever you want with it," the team writes on its funding site. "We encourage you to opt-in to share your data with our scientists, but we respect your privacy and will not force you to do so. The data is also anonymized and private."

As for whom the researchers hoped would volunteer:

Everyone! skinny, fat, sick, healthy, Coke, Pepsi, Barack Obama, Mitt Romney, babies, grandmothers, lactose intolerant, gluten allergic, happy, sad, smoker, drinker, bald, vegan, smelly, bad breath, brown hair, blue eyes, blue hair, brown eyes, Atkins diet, high carb diet, sleepy, gassy, anxious, horny, asexual, smart, dyslexic, gorgeous, pregnant, and completely average. Babies, older people, women, men...everyone!

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New Study Analyzes Heavy Metal Dancing

Parents may never understand their rock 'n' roll loving children, but scientists might. A study published online in arXiv this week seeks to explain the "mosh pit"—using physics.

To most scientists, heavy metal refers to elements on the lower end of the periodic table. But to Jesse Silverberg and Matt Bierbaum, doctoral students at Cornell University's department of Condensed Matter Physics, the aggressive music—and the violent dancing that accompanies it—could be a key to understanding extreme situations such as riots and panicked responses to disasters.

For the past two years, Silverberg and Bierbaum have studied "moshing," at heavy metal concerts, using theories of collective motion and the physical properties of gasses to better understand the chaos of metal fans' dancing.

Moshing, for those who have never attended a heavy metal show, is a form of dancing in which participants bump, jostle, and slam into one another. It's a form of social ritual that anthropologists have likened to spirit possession in its uncontrolled, dynamic, and often violent nature.

Silverberg and Bierbaum say it can also be understood by applying models of gaseous particles. As these particles float in groups, they too run, bash, and slam into each other, sending the elements flying in chaotic patterns.

"We are interested in how humans behave in similar excited states," said Silverberg, "but it's not exactly ethical to start a riot for research."

Extreme Physics

Mosh pits provided the scientists with a way to observe excited collective movement without causing undue injury or death. Analyzing hours of recorded footage from concerts and making multiple field trips to music clubs, Silverberg and Bierbaum recognized the particulate physical patterns in the mosh pit.

Further, they differentiated two distinct forms of heavy metal dancing: the "mosh pit" itself, which follows the gaseous pattern, and the "circle pit" (where dancers run, smash, and dance in a circular rotation) within it, which adheres to a vortex pattern of particulate behavior.

Based on these observations, they created an interactive computer model depicting the behavior.

Animal Instincts

"Herd animals behave in very similar spirit—what physicists call 'flocking' behavior," said Bierbaum. (See "The Genius of Swarms," from the July 2007 issue of National Geographic magazine.)

As with groups of flying birds or schooling fish, simple rules can be applied to individuals in large groups—like moshers—to understand what seems to be very complex behavior. This makes modeling possible, allowing computers to re-create immense numbers of actions in a matter of seconds. These models can then be used to design spaces that would minimize trampling or injury, or to tailor responses to disasters like fires.

"The lessons we've learned in mosh pits [could be used] to build better stadiums, or movie theaters," Silverberg said.

James Sethna, one of the researchers' advising professors, hastened to add that his students' forays into heavy metal science "didn't start out for reasons of creating safer stadiums. We did it because it was cool and we wanted to know if we could explain human behavior—albeit slightly intoxicated behavior—without having to use complex [models]."

A longtime heavy metal fan himself, Silverberg shared which band produced the best results: "Killswitch Engage ... always gets the crowd nuts. Although of course everyone has their own favorites."

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Report Fingers Chinese Military Unit in US Hacks

A Virginia-based cyber security firm has released a new report alleging a specific Chinese military unit is likely behind one of the largest cyber espionage and attack campaigns aimed at American infrastructure and corporations.

In the report, released today by Mandiant, China's Unit 61398 is blamed for stealing "hundreds of terabytes of data from at least 141 organizations" since 2006, including 115 targets in the U.S. Twenty different industrial sectors were targeted in the attacks, Mandiant said, from energy and aerospace to transportation and financial institutions.

Mandiant believes it has tracked Unit 61398 to a 12-story office building in Shanghai that could employ hundreds of workers.

"Once [Unit 61398] has established access [to a target network], they periodically revisit the victim's network over several months or years and steal broad categories of intellectual property, including technology blueprints, proprietary manufacturing processes, test results, business plans, pricing documents, partnership agreements, and emails and contact lists from victim organizations' leadership," the report says.

The New York Times, which first reported on the Mandiant paper Monday, said digital forensic evidence presented by Mandiant pointing to the 12-story Shangai building as the likely source of the attacks has been confirmed by American intelligence officials. Mandiant was the firm that The Times said helped them investigate and eventually repel cyber attacks on their own systems in China last month.

Peter Parks/AFP/Getty Images

The Chinese government has repeatedly denied involvement in cyber intrusions and Chinese Foreign Ministry spokesperson Hong Lei said today that the claims in the Mandiant report were unsupported, according to a report by The Associated Press.

"To make groundless accusations based on some rough material is neither responsible nor professional," he reportedly said.

Mandiant's report was released a week after President Obama said in his State of the Union address that America must "face the rapidly growing threat from cyber attack."

"We know hackers steal people's identities and infiltrate private e-mail. We know foreign countries and companies swipe our corporate secrets. Now our enemies are also seeking the ability to sabotage our power grid, our financial institutions, and our air traffic control systems. We cannot look back years from now and wonder why we did nothing in the face of real threats to our security and our economy," he said.

Though Obama did not reference China or any country specifically, U.S. officials have previously accused the Asian nation of undertaking a widespread cyber espionage campaign.

Referring to alleged Chinese hacking in October 2011, House Intelligence Committee Chairman Rep. Mike Rogers (R-Mich.) said in an open committee meeting that he did not believe "that there is a precedent in history for such a massive and sustained intelligence effort by a government agency to blatantly steal commercial data and intellectual property."

Rogers said that cyber intrusions into American and other Western corporations by hackers working on behalf of Beijing -- allegedly including attacks on corporate giants like Google and Lockheed Martin -- amounted to "brazen and widespread theft."

"The Chinese have proven very, very good at hacking their way into very large American companies that spend a lot of money trying to protect themselves," cyber security expert and ABC News consultant Richard Clarke said in an interview last week.

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Biofuel rush is wiping out unique American grasslands

Say goodbye to the grass. The scramble for biofuels is rapidly killing off unique grasslands and pastures in the central US.

Christopher Wright and Michael Wimberly of South Dakota State University in Brookings analysed satellite images of five states in the western corn belt. They found that 530,000 hectares of grassland disappeared under blankets of maize and soya beans between 2006 and 2011. The rate was fastest in South Dakota and Iowa, with as much as 5 per cent of pasture becoming cropland each year.

The trend is being driven by rising demand for the crops, partly through incentives to use them as fuels instead of food.

The switch from meadows to crops is causing a crash in populations of ground-nesting birds. One of the US's most important breeding grounds for wildfowl, an area called the Prairie Pothole Region, is also at risk, with South Dakota's crop fields now within 100 metres of the wetlands. "Half of North American ducks breed here," says Wright.

Bill Henwood of the Temperate Grasslands Conservation Initiative in Vancouver, Canada, says the results are distressing. "Exchanging real environmental impacts for the dubious benefits of biofuels is counterproductive," he says. "Last year's record drought in the corn belt all but wiped out the crops anyway."

Journal reference: PNAS, DOI: 10.1073/pnas.1215404110

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Greater US military role in Mali likely after polls: senator

BAMAKO: The United States is likely to play a more active military role in Mali, where French-led forces are battling Islamist rebels, after the country holds elections, the chair of a key Senate sub-committee said Monday.

Washington has been providing intelligence, transport and mid-air refuelling to France, which launched its intervention last month, but cannot work directly with the Malian army until a democratically elected government replaces current leaders who came to power after a coup, said Christopher Coons, chair of the Senate foreign relations committee's Africa sub-committee.

"There is the hope that there will be additional support from the United States in these and other areas, but ... American law prohibits direct assistance to the Malian military following the coup," Coons told journalists in the Malian capital.

"After there is a full restoration of democracy, I would think it is likely that we will renew our direct support for the Malian military," added the senator, who led a bipartisan congressional delegation to Mali to meet with interim president Dioncounda Traore and French and African defence officials.

US military aid to Mali before the March 2012 coup consisted largely of training and equipment such as vehicles, a State Department official said.

But military assistance "would obviously be resumed in a way commensurate with the current needs. Priorities would have shifted a bit," the official added.

"There could be other kinds of assistance that had there not been a coup we could have provided, or requests for things now that we can't provide."

Some US lawmakers criticised President Barack Obama's administration last week for not doing more to help France in Mali.

"This is a NATO ally fighting Al-Qaeda-linked terrorists -- it shouldn't be that hard," said House foreign affairs committee chairman Ed Royce.

The hint of greater US involvement after elections adds to the complicated calculus of picking a date for the polls.

Traore, the interim president, has said he wants elections by July 31.

But critics say that is too soon given the problems Mali still faces, including ongoing insurgent attacks, a deeply divided military and hundreds of thousands of people who have fled their homes.

The minister responsible for organising the elections, Territorial Administration Minister Moussa Sinko Coulibaly, said last week the timeline "can be changed if necessary".

France, which launched its intervention on January 11 as Al-Qaeda-linked groups that had occupied the north for 10 months made incursions into government territory, is keen to share the military burden in Mali, and has announced plans to start bringing its 4,000 troops home in March.

The European Union formally approved a military training mission Monday that will be tasked with getting Mali's under-funded army ready to secure reclaimed territory.

But France is the only Western country with combat troops on the ground, and would like to hand over to some 6,000 west African troops who are slowly being deployed to help.

Mali imploded after a coup by soldiers who blamed the government for the army's humiliation at the hands of separatist rebels in the north.

With the capital in disarray, Al-Qaeda-linked fighters hijacked the independence rebellion and took control of a territory larger than Texas.

-AFP/ac

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Dell's thin, high-res XPS 13 laptop does Linux

Dell's XPS 13 with a 1,920x1,080 display is now offered with Ubuntu.

(Credit:
Dell)

Ubuntu just went 1080p on Dell's sleekest laptop.

The 2.99-pound XPS 13 Developer Edition laptop is now available on Dell's site for $1,549.

Those specifications, with the critical exception of the Ubuntu Linux, are identical to the 1080p XPS 13 for
Windows 8.

Here are the specs:

• Operating system: Ubuntu Linux 12.04 LTS
  
• Display: 13.3-inch 1,920x1,080 panel
  
• Processor: 3rd Generation Intel Core i7-3537U
  
• Memory: 8GB2 DDR3 SDRAM at 1600MHz
  
• Storage: 256GB solid-state drive
  
• Graphics: Intel HD 4000
  
• Price: $1,549
  

In addition to the U.S., Dell will also start to roll it out in select countries in Europe, including the UK, France, Germany, Austria, Belgium, Denmark, and Finland.

The XPS 13 is one of the better ultrabook designs to emerge from a top-tier PC vendor. It squeezes a 13.3-inch screen into a footprint more typical of 12-inch laptops, boasts Gorilla Glass, and is constructed from aluminum and carbon fiber, allowing Dell to keep the weight to just under three pounds.

The upgraded display is also brighter and has wider viewing angles that the original 1,366x768 XPS 13 model.

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Confirmed: Dogs Sneak Food When People Aren't Looking

Many dog owners will swear their pups are up to something when out of view of watchful eyes. Shoes go missing, couches have mysterious teeth marks, and food disappears. They seem to disregard the word "no."

Now, a new study suggests dogs might understand people even better than we thought. (Related: "Animal Minds.")

The research shows that domestic dogs, when told not to snatch a piece of food, are more likely to disobey the command in a dark room than in a lit room.

This suggests that man's best friend is capable of understanding a human's point of view, said study leader Juliane Kaminski, a psychologist at the U.K.'s University of Portmouth.

"The one thing we can say is that dogs really have specialized skills in reading human communication," she said. "This is special in dogs." (Read "How to Build a Dog.")

Sneaky Canines

Kaminski and colleagues recruited 84 dogs, all of which were more than a year old, motivated by food, and comfortable with both strangers and dark rooms.

The team then set up experiments in which a person commanded a dog not to take a piece of food on the floor and repeated the commands in a room with different lighting scenarios ranging from fully lit to fully dark.

They found that the dogs were four times as likely to steal the food—and steal it more quickly—when the room was dark. (Take our dog quiz.)

"We were thinking what affected the dog was whether they saw the human, but seeing the human or not didn't affect the behavior," said Kaminski, whose study was published recently in the journal Animal Cognition.

Instead, she said, the dog's behavior depended on whether the food was in the light or not, suggesting that the dog made its decision based on whether the human could see them approaching the food.

"In a general sense, [Kaminski] and other researchers are interested in whether the dog has a theory of mind," said Alexandra Horowitz, head of the Dog Cognition Lab at Barnard University, who was not involved in the new study.

Something that all normal adult humans have, theory of mind is "an understanding that others have different perspective, knowledge, feelings than we do," said Horowitz, also the author of Inside of a Dog.

Smarter Than We Think

While research has previously been focused on our closer relatives—chimpanzees and bonobos—interest in dog cognition is increasing, thanks in part to owners wanting to know what their dogs are thinking. (Pictures: How smart are these animals?)

"The study of dog cognition suddenly began about 15 years ago," Horowitz said.

Part of the reason for that, said Brian Hare, director of the Duke Canine Cognition Lab and author of The Genius of Dogs, is that "science thought dogs were unremarkable."

But "dogs have a genius—years ago we didn't know what that was," said Hare, who was not involved in the new research. (See pictures of the the evolution of dogs, from wolf to woof.)

Many of the new dog studies are variations on research done with chimpanzees, bonobos, and even young children. Animal-cognition researchers are looking into dogs' ability to imitate, solve problems, or navigate social environments.

So just how much does your dog understand? It's much more than you—and science—probably thought.

Selectively bred as companions for thousands of years, dogs are especially attuned to human emotions—and, study leader Kaminski said, are better at reading human cues than even our closest mammalian relatives.

"There has been a physiological change in dogs because of domestication," Duke's Hare added. "Dogs want to bond with us in ways other species don't." (Related: "Dogs' Brains Reorganized by Breeding.")

While research reveals more and more insight into the minds of our furry best friends, Kaminski said, "We still don't know just how smart they are."

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Nike, Oakley Distance Themselves from Pistorius

Corporate sponsors of Olympic "blade runner" Oscar Pistorius have begun to distance themselves from the sprinter, who is accused of murdering his model girlfriend, Reeva Steenkamp. Pistorius is back to court in South Africa Tuesday morning on murder charges.

Oakley, the eyewear manufacturer, and the sporting goods giant Nike announced today that they would no longer run ads featuring Pistorius, the South African double-amputee who gained worldwide fame for running on carbon-fiber blades.

"In light of the recent allegations, Oakley is suspending its contract with Oscar Pistorius, effective immediately. Our hearts are with the families during this difficult time and we'll continue to follow the developments in this tragic case," Oakley spokeswoman Cheri Quigley said in a statement released this afternoon.

Earlier in the day, Nike said it had "no plans" to use Pistorius in future ad campaigns, according to the Associated Press. Nike had already pulled an Internet ad showing Pistorius starting to sprint with the caption, "I am the bullet in the chamber."

The companies made their announcements shortly after Pistorius' own agent, Peet Van Zyl, said publicly that he expected the sponsors to stick with Pistorius through the legal process.

PHOTOS: Paralympic Champion Charged in Killing

Pistorius will appear in court Tuesday morning for a bail hearing. His attorneys are expected to argue against the charge of premeditated murder.

His family has said the shooting was an accident.

The news comes as more details emerge about the incident on Thursday morning in which Pistorius allegedly shot and killed Steenkamp at his gated home in Pretoria, South Africa.

Bryn Lennon; Gallo Images/Getty Images

Oscar Pistorius: Possibly Incriminating Information Leaked Watch Video

'Blade Runner' Murder Charges: Family Insist Accidental Shooting Watch Video

'Blade Runner' Murder Mystery: Family Speaks Out Watch Video

News reports in local papers have said that police are investigating whether Pistorius had an anger-management problem that led to the incident. They focused in on a bloodied cricket bat that may have been used when Steenkamp died.

A "shocked" teammate of Oscar Pistorius rebutted the rumors and speculation in South Africa that Pistorius had an anger problem.

Ofentse Mogawane, a sprinter for the South African Olympic team who ran the 400-meter relay with Pistorius in the London summer games last year, said Pistorius had always been genial to him and other people.

Mogawane said he would be in court Tuesday to support his friend.

"Basically, he was a very good guy to us, to the teammates and to most athletes," Mogawane said. "He was a really humble person and I wouldn't say a bad word about him. We never had any kind of clash, never any kind of fight or disagreement or arguing.

"The way Oscar's case was, it shocked me, shocked most of the people who know him. Tomorrow in court I am going to be there to support him. To hear what happened the night of the incident," he said.

"Sometimes when people are angry they cannot control their anger. Something must have happened."

Mogawane, 30, spoke in support of Pistorius after a report in South Africa's City Press newspaper that claimed police were looking into the possibility that a bloody cricket bat found in his bedroom was used before the shooting.

"The way the news has been running around in South Africa, that he is a short-tempered person, a person who has problems with anger management, they just want something to say," Mogawane said. "They don't know Oscar at all. They just want to get interviewed and take pictures. But truly speaking, it's just a lot of speculation."

Mogawane said he had seen Pistorius become angry before, but only in the same way as any other athlete or person.

But the City Press reported Sunday that police are investigating different scenarios involving the bat. Among them is the possibility that the flat-fronted bat was used in a violent argument before the shooting.

The paper also reported that Pistorius might have first shot Steenkamp in the bedroom, and that she possibly fled to the bathroom where she was shot three more times through the door.

When Pistorius' family arrived at the scene before paramedics, they saw him carrying Steenkamp down the stairs and performing mouth-to-mouth resuscitation on her, City Press reported.

Pistorius, who is nicknamed the "blade runner" because of the carbon-fiber blades on which he runs, has canceled all his upcoming racing appearances, his agent said Sunday night.

The decision was made to "allow Oscar to concentrate on the upcoming legal proceedings and to help and support all those involved as they try to come to terms with this very difficult and distressing situation," Van Zyl, of In Site Athlete Management, said in a statement.

Pistorius' father was quoted overnight in the South African paper The Sunday Times saying his countrymen are destroying a national icon.

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Wiping out top predators messes up the climate

Wiping out top predators like lions, wolves and sharks is tragic, bad for ecosystems – and can make climate change worse. Mass extinctions of the big beasts of the jungles, grasslands and oceans could already be adding to greenhouse gases in the atmosphere.

Trisha Atwood of the University of British Columbia in Vancouver, Canada, studied the effect of removing predator fish from ponds and rivers in Canada and Costa Rica. Across a range of ecosystems, climates and predators, she found a consistent pattern: carbon dioxide emissions typically increased more than tenfold after the predators were removed.

"It looks like predators in many types of ecosystems – marine and terrestrial as well as freshwater – can play a very big role in global climate change," she told New Scientist.

The widespread and dramatic ecological impacts of the loss of top predators are well known. In the ensuing "trophic cascade", the vanished top predator's prey proliferate, which in turn puts pressure on the species that the prey eats, and so on down the food chain. In this way, changes at the top of a food chain destabilise the balance of populations right the way down.

But the geochemical impacts of trophic cascades, including any impact on emissions from ecosystems, are much less well known. Atwood's study of freshwater ecosystems showed how changes to species at the bottom of the food chain, such as photosynthesising algae, following the removal of a top predator dramatically increased the flow of CO₂ from the ecosystem to the atmosphere.

The effect will not always be to increase CO₂ emissions, however – sometimes the loss of top predators could decrease emissions, she says. "But we show that something so seemingly unrelated, like fishing all the trout from a pond or removing sharks from the ocean, could have big consequences for greenhouse-gas dynamics."

Help from kelp

Other recent studies have hinted at similar effects. Last October, Christopher Wilmers of the University of California, Santa Cruz, reported how the disappearance of sea otters is linked with increased CO₂ emissions from North American coastlines (Frontiers in Ecology and the Environment, doi.org/khz). With no otters eating them, sea urchins thrive and eat out kelp forests – often known as the "rainforests of the oceans" – resulting in major CO₂ releases.

Global climate models do not take such impacts into account yet. Atwood says they could be major, as freshwater emissions may be on a par with the influence of deforestation, which is thought responsible for around 15 per cent of human-caused CO₂ emissions.

Environmentalists will herald the findings as further evidence that it is vital to protect pristine habitats and the charismatic species at the top of their food chains. But there is a dark side. A recent study found that some island ecosystems around New Zealand store 40 per cent more carbon than others because of their top predators – invading rats that are wiping out seabird colonies. Rats, it seems, are good for the climate (Biology Letters, doi.org/bbmtw9).

Journal reference: Nature Geoscience, DOI: 10.1038/NGEO1734

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Helicopter scandal hangs over Cameron's India visit

NEW DELHI: British Prime Minister David Cameron arrives in India's financial hub Mumbai on Monday on a three-day trade-focused visit clouded by a corruption scandal over British-made helicopters sold to New Delhi.

Cameron's trip comes amid a raging scandal over the procurement of 12 helicopters for use by VIPs in 2010, which were bought for $748 million (560 million euros) from Anglo-Italian firm AgustaWestland.

After an investigation in Italy suggested kickbacks were paid via middlemen to secure the deal, India has taken steps to cancel the contract and has started its own police investigation.

The British prime minister is likely to face further questions about the contract -- the helicopters are being manufactured in southwest Britain -- with the Indian government keen to be seen to be acting tough on a new graft scandal.

"We did ask (Britain) in November and they said that since the Italians are investigating let us await the outcome (of that probe)," Indian foreign ministry spokesman Syed Akbaruddin told AFP.

Indian investigators will travel to Italy as ealy as this week as part of an inquiry into the matter, a spokesperson for the Delhi-based Central Bureau of Investigation (CBI) said Sunday.

Cameron, who will be accompanied by a large business delegation, will be far keener to address new areas for trade and investment between Britain and its former colony, whose economy has slowed sharply but still offers vast potential.

The British leader has targeted a doubling of trade with India from 11.5 billion pounds ($17.8 billion, 13.4 billion euros) in 2010 to 23 billion pounds by the time he faces re-election in 2015.

After business meetings in Mumbai on Monday, he will fly to New Delhi for face-to-face talks with Indian Prime Minister Manmohan Singh and President Pranab Mukherjee on Tuesday.

On his first trip to the country in 2010 after his election, Cameron pressed the case for the part-British Eurofighter jet, which was competing to win a $12-billion contract for 126 aircraft.

Last January, India selected a rival French plane, the Rafale made by Dassault Aviation, but with the deal still not finalised Cameron is likely to remind the Indian government of the Eurofighter's merits.

Among his business delegation, executives from the Tesco supermarket chain are eyeing the retail sector following recent reforms to open up the market, as are bosses from the banking and insurance world.

On his last trip to India in 2010, Cameron issued an unexpectedly blunt warning to India's arch-rival Pakistan about promoting "the export of terror", which played well in New Delhi but provoked a furious response in Islamabad.

Pakistan's ambassador to Britain accused Cameron of "damaging the prospects of regional peace".

Cameron also stressed during the trip that he had come to India "in a spirit of humility" in a deliberate attempt to distance himself from previous visiting British politicians who have upset their hosts.

In 2009, then British foreign minister David Miliband ignited a diplomatic furore when he linked the 2008 Mumbai attacks to the lack of a solution in divided Kashmir.

India resents any foreign involvement in the Himalayan region, which it sees as a bilateral issue between it and Pakistan.

As well as trade, Cameron will also use the trip to correct any misunderstandings about his government's drive to slash immigration numbers amid concerns that young Indians could be deterred from applying to study in Britain.

-AFP/ac

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